NDST3

This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]

Description

N-deacetylase and N-sulfotransferase 3

Tissue specificity

Group enriched (brain, liver, lymphoid tissue, retina)

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

4 (118033618 - 118258634)

Ensembl ID

ENSG00000164100  (ver. 103.38)

Orthologs

Mouse Ndst3: ENSMUSG00000027977

UniProt

O95803

neXtProt

NX_O95803

Human splice variants
Mouse splice variants

Protein structure