TAF1B

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Description

TATA-box binding protein associated factor, RNA polymerase I subunit B

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

2 (9843443 - 9934416)

Ensembl ID

ENSG00000115750  (ver. 103.38)

Orthologs

Mouse Taf1b: ENSMUSG00000059669

UniProt

Q53T94

neXtProt

NX_Q53T94

Human splice variants
Mouse splice variants

Protein structure