CHST15

Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Description

Carbohydrate sulfotransferase 15

Tissue specificity

Low tissue specificity

Subcell location

Centrosome, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

10 (124007668 - 124093598)

Ensembl ID

ENSG00000182022  (ver. 103.38)

Orthologs

Mouse Chst15: ENSMUSG00000030930

UniProt

Q7LFX5

neXtProt

NX_Q7LFX5

Human splice variants
Mouse splice variants

Protein structure