DOC2A

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Description

Double C2 domain alpha

Tissue specificity

Tissue enhanced (brain, testis)

Subcell location

Nucleoplasm, Nucleoli, Cell Junctions

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

16 (30005514 - 30023270)

Ensembl ID

ENSG00000149927  (ver. 103.38)

Orthologs

Mouse Doc2a: ENSMUSG00000052301

UniProt

Q14183

neXtProt

NX_Q14183

Human splice variants
Mouse splice variants

Protein structure