MAP3K12

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2010]

Description

Mitogen-activated protein kinase kinase kinase 12

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (53479669 - 53500063)

Ensembl ID

ENSG00000139625  (ver. 103.38)

Orthologs

Mouse Map3k12: ENSMUSG00000023050

UniProt

Q12852

neXtProt

NX_Q12852

Human splice variants
Mouse splice variants

Protein structure