AF662

antibody from R&D Systems

Targeting: OSMR OSMRB, OSMRbeta

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

AF662

Provider

R&D Systems

Product name

Mouse OSMR beta Antibody

Antibody type

Polyclonal

Description

Immunogen affinity purified. Detects mouse OSM R beta in direct ELISAs and Western blots.

Reactivity

Mouse

Host

Goat

Conjugate

Unconjugated

Antigen sequence

O70458


Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis.

Martínez-Fábregas J, Prescott A, van Kasteren S, Pedrioli DL, McLean I, Moles A, Reinheckel T, Poli V, Watts C
Nature communications 2018 Dec 17;9(1):5343

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Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo.

Elks CM, Zhao P, Grant RW, Hang H, Bailey JL, Burk DH, McNulty MA, Mynatt RL, Stephens JM
The Journal of biological chemistry 2016 Aug 12;291(33):17066-76

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Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury.

Guihard P, Boutet MA, Brounais-Le Royer B, Gamblin AL, Amiaud J, Renaud A, Berreur M, Rédini F, Heymann D, Layrolle P, Blanchard F
The American journal of pathology 2015 Mar;185(3):765-75

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Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.

Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y
The Journal of biological chemistry 2014 May 16;289(20):13821-37

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Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.

Le Goff B, Singbrant S, Tonkin BA, Martin TJ, Romas E, Sims NA, Walsh NC
Cytokine 2014 Aug;68(2):101-9

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Lack of oncostatin M receptor β leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype.

Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y
The Journal of biological chemistry 2013 Jul 26;288(30):21861-75

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A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor.

Chollangi S, Mather T, Rodgers KK, Ash JD
The Journal of biological chemistry 2012 Sep 21;287(39):32848-59

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Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.

Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C
The Journal of biological chemistry 2011 Sep 30;286(39):34271-85