BS7715

antibody from Bioworld Technology, Inc
Targeting: BAG6 BAT3, D6S52E, G3, Scythe
Provider product page for BS7715
Western blot
Immunohistochemistry

Antibody data

Product number
BS7715 - Provider product page
Provider
Bioworld Technology, Inc
Product name
BAT3 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human BAT3.
Description
BAT3 (HLA-B associated transcript 3), also known as G3, scythe, BAG6 or D6S52E, is a proline-rich nuclear protein with an important role as an apoptotic regulator. BAT3 contains one ubiquitin-like domain at its N-terminus and two nuclear localization signals at its C-terminus. Specifically, BAT3 interacts with and stabilizes AIF (apoptosis inducing factor), thereby sensitizing the cell to apoptosis mediated by endoplasmic reticulum (ER) stress. Upon ricin treatment, BAT3 is cleaved by caspase-3 and its C-terminal fragment displays pro-apoptotic activities. The apoptotic activities executed include nuclear condensation, phosphatidlyserine externalization, cell rounding and shrinkage. Mice that are deficient in BAT3 exhibit pronounced defects in lung, brain and kidney development and in the regulation of proliferation and apoptosis. These defects ultimately result in perinatal or midgestational lethality.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BAG6 protein structure - BS7715 shown in red.