NGLY1

This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Description

N-glycanase 1

Protein family

Disease related genes, Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Peptideatlas)

Chromosome

3:p24.2 (25718944 - 25790039)

Ensembl ID

ENSG00000151092  (ver. 99.38)

Orthologs

Mouse Ngly1: ENSMUSG00000021785

UniProt

Q96IV0

neXtProt

NX_Q96IV0

Human splice variants
Mouse splice variants