LRIG2

This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Description

Leucine rich repeats and immunoglobulin like domains 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Golgi apparatus

Predicted location

Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (113073198 - 113132260)

Ensembl ID

ENSG00000198799  (ver. 103.38)

Orthologs

Mouse Lrig2: ENSMUSG00000032913

UniProt

O94898

neXtProt

NX_O94898

Human splice variants
Mouse splice variants

Protein structure