KCNE3

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]

Description

Potassium voltage-gated channel subfamily E regulatory subunit 3

Tissue specificity

Tissue enhanced (intestine, stomach)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

11 (74454841 - 74467729)

Ensembl ID

ENSG00000175538  (ver. 103.38)

Orthologs

Mouse Kcne3: ENSMUSG00000035165

UniProt

Q9Y6H6

neXtProt

NX_Q9Y6H6

Human splice variants
Mouse splice variants

Protein structure