EIF4ENIF1

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Description

Eukaryotic translation initiation factor 4E nuclear import factor 1

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (31436977 - 31496108)

Ensembl ID

ENSG00000184708  (ver. 103.38)

Orthologs

Mouse Eif4enif1: ENSMUSG00000020454

UniProt

Q9NRA8

neXtProt

NX_Q9NRA8

Human splice variants
Mouse splice variants

Protein structure