UBA52

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]

Description

Ubiquitin A-52 residue ribosomal protein fusion product 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Endoplasmic reticulum, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Ribosomal proteins

Chromosome

19 (18571730 - 18577550)

Ensembl ID

ENSG00000221983  (ver. 103.38)

Orthologs

Mouse Uba52: ENSMUSG00000090137

UniProt

P62987

neXtProt

NX_P62987

Human splice variants
Mouse splice variants

Protein structure