FNIP2

This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]

Description

Folliculin interacting protein 2

Tissue specificity

Low tissue specificity

Subcell location

Centriolar satellite, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

4 (158769026 - 158908050)

Ensembl ID

ENSG00000052795  (ver. 103.38)

Orthologs

Mouse Fnip2: ENSMUSG00000061175

UniProt

Q9P278

neXtProt

NX_Q9P278

Human splice variants
Mouse splice variants

Protein structure