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RAPGEF2
Rap guanine nucleotide exchange factor 2DKFZP586O1422, KIAA0313, PDZ-GEF1, PDZGEF1, RA-GEF
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]). [supplied by OMIM, Mar 2008]
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| antibodies-online |  ABIN438495 |
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| Novus Biologicals | NBP1-06549 |
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| Invitrogen Antibodies | A301-966A |
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| NSJ Bioreagents | RQ6152 |
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| Boster Biological Technology | A04621-1 |
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