LRRFIP2

The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]

Description

LRR binding FLII interacting protein 2

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Actin filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

3 (37052626 - 37183689)

Ensembl ID

ENSG00000093167  (ver. 103.38)

Orthologs

Mouse Lrrfip2: ENSMUSG00000032497

UniProt

Q9Y608

neXtProt

NX_Q9Y608

Human splice variants
Mouse splice variants

Protein structure