GPAA1

Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008]

Description

Glycosylphosphatidylinositol anchor attachment 1

Tissue specificity

Low tissue specificity

Subcell location

Endoplasmic reticulum, Centrosome, Mitochondria, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (144082590 - 144086216)

Ensembl ID

ENSG00000197858  (ver. 103.38)

Orthologs

Mouse Gpaa1: ENSMUSG00000022561

UniProt

O43292

neXtProt

NX_O43292

Human splice variants
Mouse splice variants

Protein structure