HOMER3

This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Description

Homer scaffold protein 3

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Plasma membrane, Cytosol, Cytoplasmic bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (18929201 - 18941261)

Ensembl ID

ENSG00000051128  (ver. 103.38)

Orthologs

-

UniProt

Q9NSC5

neXtProt

NX_Q9NSC5

Human splice variants

Protein structure