MAP3K8

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Description

Mitogen-activated protein kinase kinase kinase 8

Tissue specificity

Tissue enriched (bone marrow)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

10 (30434021 - 30461833)

Ensembl ID

ENSG00000107968  (ver. 103.38)

Orthologs

Mouse Map3k8: ENSMUSG00000024235

UniProt

P41279

neXtProt

NX_P41279

Human splice variants
Mouse splice variants

Protein structure