TNMD

This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]

Description

Tenomodulin

Tissue specificity

Tissue enhanced (adipose tissue, breast, seminal vesicle)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

X (100584936 - 100599885)

Ensembl ID

ENSG00000000005  (ver. 103.38)

Orthologs

Mouse Tnmd: ENSMUSG00000031250

UniProt

Q9H2S6

neXtProt

NX_Q9H2S6

Human splice variants
Mouse splice variants

Protein structure