PDE3A

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Description

Phosphodiesterase 3A

Tissue specificity

Tissue enhanced (heart muscle)

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (20368537 - 20688583)

Ensembl ID

ENSG00000172572  (ver. 103.38)

Orthologs

Mouse Pde3a: ENSMUSG00000041741

UniProt

Q14432

neXtProt

NX_Q14432

Human splice variants
Mouse splice variants

Protein structure