SCN11A

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]

Description

Sodium voltage-gated channel alpha subunit 11

Tissue specificity

Tissue enhanced (lymphoid tissue, placenta)

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Chromosome

3 (38845764 - 39052157)

Ensembl ID

ENSG00000168356  (ver. 103.38)

Orthologs

Mouse Scn11a: ENSMUSG00000034115

UniProt

Q9UI33

neXtProt

NX_Q9UI33

Human splice variants
Mouse splice variants

Protein structure