FBXW11

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

Description

F-box and WD repeat domain containing 11

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Vesicles, Plasma membrane

Predicted location

Intracellular

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (171861549 - 172006873)

Ensembl ID

ENSG00000072803  (ver. 103.38)

Orthologs

Mouse Fbxw11: ENSMUSG00000020271

UniProt

Q9UKB1

neXtProt

NX_Q9UKB1

Human splice variants
Mouse splice variants

Protein structure