Tissue expression
Cell line expression
Protein structure
UNC45B
Unc-45 myosin chaperone BCMYA4, UNC45
This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Top validated antibodies |
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Novus Biologicals | H00146862-B01P | 1 references | Polyclonal |
WB
ICC
IHC
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|
Proteintech Group | 21640-1-AP | Polyclonal |
WB
EL
IHC
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Biorbyt | orb1286267 | Polyclonal |
WB
EL
IHC
|
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Invitrogen Antibodies | 21640-1-AP | Polyclonal |
WB
IHC |
||
antibodies-online | ABIN4364359 | Polyclonal |
WB
ICC
IHC
|
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