TMEFF2

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Description

Transmembrane protein with EGF like and two follistatin like domains 2

Tissue specificity

Tissue enhanced (brain, prostate, seminal vesicle)

Predicted location

Membrane, Secreted in male reproductive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (191949043 - 192194933)

Ensembl ID

ENSG00000144339  (ver. 103.38)

Orthologs

Mouse Tmeff2: ENSMUSG00000026109

UniProt

Q9UIK5

neXtProt

NX_Q9UIK5

Human splice variants
Mouse splice variants

Protein structure