PRC1

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Description

Protein regulator of cytokinesis 1

Tissue specificity

Tissue enhanced (bone marrow, testis)

Subcell location

Nucleoplasm, Plasma membrane, Microtubules, Cytokinetic bridge, Midbody

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

15 (90966040 - 90995629)

Ensembl ID

ENSG00000198901  (ver. 103.38)

Orthologs

Mouse Prc1: ENSMUSG00000038943

UniProt

O43663

neXtProt

NX_O43663

Human splice variants
Mouse splice variants

Protein structure