ATP23

The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Description

ATP23 metallopeptidase and ATP synthase assembly factor homolog

Tissue specificity

Tissue enhanced (testis)

Subcell location

Vesicles, Plasma membrane, Cell Junctions, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

12 (57906039 - 57959148)

Ensembl ID

ENSG00000166896  (ver. 103.38)

Orthologs

Mouse Atp23: ENSMUSG00000025436

UniProt

Q9Y6H3

neXtProt

NX_Q9Y6H3

Human splice variants
Mouse splice variants

Protein structure