SV2B

This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016]

Description

Synaptic vesicle glycoprotein 2B

Tissue specificity

Group enriched (brain, retina)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

15 (91099950 - 91302565)

Ensembl ID

ENSG00000185518  (ver. 103.38)

Orthologs

Mouse Sv2b: ENSMUSG00000053025

UniProt

Q7L1I2

neXtProt

NX_Q7L1I2

Human splice variants
Mouse splice variants

Protein structure