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Protein structure
CAVIN1
Caveolae associated protein 1cavin-1, CGL4, PTRF
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]
Top validated antibodies |
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| Proteintech Group |  18892-1-AP |
19 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | 18892-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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| Novus Biologicals | NBP1-44089 |
2 references | Polyclonal |
WB
EL
ICC
IHC
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| NovoPro Bioscience Inc. | 114332 |
Polyclonal |
WB
EL
ICC
IP
IHC
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| Wuhan Fine Biotech Co., Ltd. | FNab06950 |
Polyclonal |
WB
EL
ICC
IP
IHC
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