RGS14

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Description

Regulator of G protein signaling 14

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Vesicles, Plasma membrane, Intermediate filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (177357924 - 177372596)

Ensembl ID

ENSG00000169220  (ver. 103.38)

Orthologs

Mouse Rgs14: ENSMUSG00000052087

UniProt

O43566

neXtProt

NX_O43566

Human splice variants
Mouse splice variants

Protein structure