PADI2

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

Description

Peptidyl arginine deiminase 2

Tissue specificity

Tissue enhanced (brain, skeletal muscle, tongue)

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (17066761 - 17119451)

Ensembl ID

ENSG00000117115  (ver. 103.38)

Orthologs

Mouse Padi2: ENSMUSG00000028927

UniProt

Q9Y2J8

neXtProt

NX_Q9Y2J8

Human splice variants
Mouse splice variants

Protein structure