Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
HAMP
Hepcidin antimicrobial peptideHEPC, HFE2B, LEAP-1, LEAP1
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]
Top validated antibodies |
|||||
| antibodies-online |  ABIN394071 |
5 references | Monoclonal |
WB
EL
IHC
|
|
| Novus Biologicals | NBP1-36960 |
2 references | Polyclonal |
WB
EL
IHC
|
|
| OriGene | AM21007PU-N |
Monoclonal |
WB
EL
IHC
|
||
| Acris Antibodies GmbH | AM21007PU-N |
Monoclonal |
WB
EL
IHC
|
||
| Cusabio Biotech Co., Ltd | CSB-PA010124KA01HU |
Polyclonal |
WB
EL
IHC
|
||
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider