CDC42EP3

This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Description

CDC42 effector protein 3

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Actin filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (37641882 - 37738468)

Ensembl ID

ENSG00000163171  (ver. 103.38)

Orthologs

Mouse Cdc42ep3: ENSMUSG00000036533

UniProt

Q9UKI2

neXtProt

NX_Q9UKI2

Human splice variants
Mouse splice variants

Protein structure