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G6PC
Glucose-6-phosphatase catalytic subunitG6PC1, G6PT, GSD1a
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys. [provided by RefSeq, Feb 2011]
Top validated antibodies |
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| antibodies-online |  ABIN2840227 |
2 references | Polyclonal |
WB
IHC
FC
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| Proteintech Group | 22169-1-AP |
16 references | Polyclonal |
EL
IHC
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| Invitrogen Antibodies | PA5-42541 |
2 references | Polyclonal |
WB
IHC
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| Enzo Life Sciences | ADI-VAP-PT034-C |
2 references | Polyclonal |
WB
ICC
IP
IHC
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| Abgent | AP5224c |
Polyclonal |
WB
IHC
FC
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