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SOST
SclerostinDAND6, VBCH
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  21933-1-AP |
4 references | Polyclonal |
WB
EL
ICC
IHC
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| R&D Systems | AF1589 |
38 references | Polyclonal |
WB
IHC
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| Novus Biologicals | AF1589 |
47 references | Polyclonal |
WB
IHC
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| antibodies-online | ABIN2840682 |
2 references | Polyclonal |
WB
IHC
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| Abnova Corporation | PAB4841 |
3 references | Polyclonal |
WB
IHC
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