SNX15

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]

Description

Sorting nexin 15

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli, Vesicles, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (65027439 - 65040572)

Ensembl ID

ENSG00000110025  (ver. 103.38)

Orthologs

Mouse Snx15: ENSMUSG00000024787

UniProt

Q9NRS6

neXtProt

NX_Q9NRS6

Human splice variants
Mouse splice variants

Protein structure