PLA2G2A

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene. [provided by RefSeq, Sep 2009]

Description

Phospholipase A2 group IIA

Tissue specificity

Group enriched (adipose tissue, intestine, placenta, urinary bladder)

Predicted location

Intracellular, Secreted to blood

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

1 (19975431 - 19980416)

Ensembl ID

ENSG00000188257  (ver. 103.38)

Orthologs

Mouse Pla2g2a: ENSMUSG00000058908

UniProt

P14555

neXtProt

NX_P14555

Human splice variants
Mouse splice variants

Protein structure