ADAM22

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants. [provided by RefSeq, Dec 2010]

Description

ADAM metallopeptidase domain 22

Tissue specificity

Tissue enriched (brain)

Subcell location

Cell Junctions

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (87934143 - 88202889)

Ensembl ID

ENSG00000008277  (ver. 103.38)

Orthologs

Mouse Adam22: ENSMUSG00000040537

UniProt

Q9P0K1

neXtProt

NX_Q9P0K1

Human splice variants
Mouse splice variants

Protein structure