TMTC2

The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Description

Transmembrane O-mannosyltransferase targeting cadherins 2

Tissue specificity

Tissue enriched (brain)

Subcell location

Plasma membrane, Actin filaments

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (82686880 - 83134870)

Ensembl ID

ENSG00000179104  (ver. 103.38)

Orthologs

Mouse Tmtc2: ENSMUSG00000036019

UniProt

Q8N394

neXtProt

NX_Q8N394

Human splice variants
Mouse splice variants

Protein structure