UBXN8

p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Description

UBX domain protein 8

Tissue specificity

Tissue enhanced (ovary)

Subcell location

Nucleoplasm, Nucleoli, Endoplasmic reticulum

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

8 (30729131 - 30767006)

Ensembl ID

ENSG00000104691  (ver. 103.38)

Orthologs

Mouse Ubxn8: ENSMUSG00000052906

UniProt

O00124

neXtProt

NX_O00124

Human splice variants
Mouse splice variants

Protein structure