SPAM1 antibody from Leading Biology
HYAL5, PH-20, SPAG15
Western blot
Recommended by provider

Antibody data

Product number
Leading Biology
Product name
SPAM1 Antibody (C-term)
Provider product page
Leading Biology - APR04381G
Antibody type
Hyaluronidase degrades hyaluronic acid, a major structuralproteoglycan found in extracellular matrices and basementmembranes. Six members of the hyaluronidase family are clusteredinto two tightly linked groups on chromosome 3p21.3 and 7q31.3.This gene was previously referred to as HYAL1 and HYA1 and hassince been assigned the official symbol SPAM1; another familymember on chromosome 3p21.3 has been assigned HYAL1. This geneencodes a GPI-anchored enzyme located on the human sperm surfaceand inner acrosomal membrane. This multifunctional protein is ahyaluronidase that enables sperm to penetrate through thehyaluronic acid-rich cumulus cell layer surrounding the oocyte, areceptor that plays a role in hyaluronic acid induced cellsignaling, and a receptor that is involved in sperm-zona pellucidaadhesion. Abnormal expression of this gene in tumors has implicatedthis protein in degradation of basement membranes leading to tumorinvasion and metastasis. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Provider Type Product Number
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