ERVW-1

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

Description

Endogenous retrovirus group W member 1, envelope

Tissue specificity

Tissue enriched (placenta)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Transporters

Chromosome

7 (92468380 - 92477986)

Ensembl ID

ENSG00000242950  (ver. 103.38)

Orthologs

Mouse Gm14226: ENSMUSG00000084897

UniProt

Q9UQF0

neXtProt

NX_Q9UQF0

Human splice variants
Mouse splice variants

Protein structure