Tissue expression
Cell line expression
Protein structure
SF3B3
Splicing factor 3b subunit 3KIAA0017, RSE1, SAP130, SF3b130
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Proteintech Group | 14577-1-AP | 9 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
Invitrogen Antibodies | 14577-1-AP | Polyclonal |
WB
ICC
IP
IHC
OA
|
||
Novus Biologicals | NB100-1077 | 4 references | Polyclonal |
WB
EL
IHC
|
|
NovoPro Bioscience Inc. | 115138 | Polyclonal |
WB
EL
ICC
IP
IHC
|
||
Biorbyt | orb1402085 | Polyclonal |
WB
EL
ICC
IHC
FC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider