FBXW12

Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). [supplied by OMIM, Mar 2008]

Description

F-box and WD repeat domain containing 12

Tissue specificity

Tissue enriched (pancreas)

Subcell location

Vesicles, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (48372219 - 48401259)

Ensembl ID

ENSG00000164049  (ver. 103.38)

Orthologs

-

UniProt

Q6X9E4

neXtProt

NX_Q6X9E4

Human splice variants

Protein structure