SPRED3

This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Description

Sprouty related EVH1 domain containing 3

Tissue specificity

Group enriched (brain, pituitary gland)

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

19 (38388421 - 38399587)

Ensembl ID

ENSG00000188766  (ver. 103.38)

Orthologs

Mouse Spred3: ENSMUSG00000037239

UniProt

Q2MJR0

neXtProt

NX_Q2MJR0

Human splice variants
Mouse splice variants

Protein structure