TAF8

This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Description

TATA-box binding protein associated factor 8

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

6:p21.1 (42050513 - 42087461)

Ensembl ID

ENSG00000137413  (ver. 99.38)

Orthologs

Mouse Taf8: ENSMUSG00000023980

UniProt

Q7Z7C8

neXtProt

NX_Q7Z7C8

Human splice variants
Mouse splice variants