LIPF

This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Description

Lipase F, gastric type

Tissue specificity

Tissue enriched (stomach)

Predicted location

Secreted to digestive system

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (88664441 - 88678814)

Ensembl ID

ENSG00000182333  (ver. 103.38)

Orthologs

Mouse Lipf: ENSMUSG00000024768

UniProt

P07098

neXtProt

NX_P07098

Human splice variants
Mouse splice variants

Protein structure