ERLEC1

This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]

Description

Endoplasmic reticulum lectin 1

Tissue specificity

Low tissue specificity

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

2 (53787044 - 53818819)

Ensembl ID

ENSG00000068912  (ver. 103.38)

Orthologs

Mouse Erlec1: ENSMUSG00000020311

UniProt

Q96DZ1

neXtProt

NX_Q96DZ1

Human splice variants
Mouse splice variants

Protein structure