STK26

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Description

Serine/threonine kinase 26

Tissue specificity

Tissue enhanced (bone marrow, epididymis)

Subcell location

Nucleoplasm, Golgi apparatus, Centrosome, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (132023302 - 132075943)

Ensembl ID

ENSG00000134602  (ver. 103.38)

Orthologs

Mouse Stk26: ENSMUSG00000031112

UniProt

Q9P289

neXtProt

NX_Q9P289

Human splice variants
Mouse splice variants

Protein structure