FBXO27

Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). [supplied by OMIM, Mar 2008]

Description

F-box protein 27

Tissue specificity

Tissue enhanced (skin)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (38990714 - 39032785)

Ensembl ID

ENSG00000161243  (ver. 103.38)

Orthologs

Mouse Fbxo27: ENSMUSG00000037463

UniProt

Q8NI29

neXtProt

NX_Q8NI29

Human splice variants
Mouse splice variants

Protein structure