KCNMB3

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]

Description

Potassium calcium-activated channel subfamily M regulatory beta subunit 3

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Mitochondria

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Chromosome

3 (179236691 - 179267002)

Ensembl ID

ENSG00000171121  (ver. 103.38)

Orthologs

Mouse Kcnmb3: ENSMUSG00000091091

UniProt

Q9NPA1

neXtProt

NX_Q9NPA1

Human splice variants
Mouse splice variants

Protein structure